Liposomal doxorubicin-induced palmoplantar erythrodysthesia syndrome
نویسندگان
چکیده
منابع مشابه
Skin problems associated with pegylated liposomal doxorubicin-more than palmoplantar erythrodysesthesia syndrome.
Liposomal pegylated doxorubicin is an encapsulation form of doxorubicin, with an improved pharmacokinetic profile and the ability to selectively accumulate into tumor tissue. As a result, the tolerated dose of the drug can be increased, followed by a reduced incidence of neutropenia and cardiotoxicity in comparison to doxorubucin treatment. However, a common adverse dose-schedule limiting effec...
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137 K .M. was a 69-year-old woman who presented to her primary physician with bloating, abdominal cramping, and constipation over the previous weeks. She also noted some fullness in her right groin. She underwent an abdominal ultrasound, which revealed an adnexal mass on the right side of her abdomen, and a computed tomography (CT) scan, which demonstrated a large complex mass in the region of ...
متن کاملLiposomal doxorubicin.
Doxorubicin is a potent antineoplastic agent with activity against numerous human cancers. Encapsulation of doxorubicin inside a liposome alters bioavailability, biodistribution and thus its biological activity significantly. The physical properties of the liposome (size, lipid components and lipid dose) play a major role in determining drug retention and pharmacokinetics. The therapeutic benef...
متن کاملModeling pegylated liposomal doxorubicin-induced hand-foot syndrome and intestinal mucositis in zebrafish
Pegylated liposomal doxorubicin (PLD) has been widely used to treat cancer. The adverse effects of PLD noted in clinical practice, especially hand-foot syndrome (HFS), are regarded as unique, and the management methods for them remain limited. This study was aimed at developing a feasible experimental model for translational medicine to solve this clinical issue by using skin fluorescent transg...
متن کاملDoxorubicin-induced chronic cardiotoxicity and its protection by liposomal administration.
The chronic cardiotoxicity of doxorubicin as a free drug or entrapped in positive and negative liposomes was morphologically evaluated in mice treated seven times i.v. at a dose of 4 mg/kg. Liposomes were composed of phosphatidylcholine, cholesterol, and stearylamine (positive charge) or phosphatidylserine (negative charge). Administration of free doxorubicin caused a pattern of cardiac damage ...
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ژورنال
عنوان ژورنال: Indian Dermatology Online Journal
سال: 2015
ISSN: 2229-5178
DOI: 10.4103/2229-5178.164488